| Patients with CD36 Deficiency Are Associated with Enhanced Atherosclerotic Cardiovascular Diseases. | |
| | |
MedLine Citation:
|
PMID: 22075538 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients.Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of (123)I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n =319) and healthy subjects (n =1,239) were underwent.Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p <0.0001).Conclusion: The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic. |
| | |
Authors:
|
Miyako Yuasa-Kawase; Daisaku Masuda; Taiji Yamashita; Ryota Kawase; Hajime Nakaoka; Miwako Inagaki; Kazuhiro Nakatani; Kazumi Tsubakio-Yamamoto; Tohru Ohama; Akifumi Matsuyama; Makoto Nishida; Masato Ishigami; Toshiharu Kawamoto; Issei Komuro; Shizuya Yamashita |
Related Documents
:
|
8200268 - Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatit... 17008278 - The prognostic significance of angiogenesis and the effect of vascular endothelial grow... 632858 - Long-term follow-up review of patients with acute and subacute subdural hematomas. 21681648 - Diagnostic ability of mdct to assess right hepatic artery invasion by perihilar cholang... 14871248 - Spleen neoangiogenesis in patients with myelofibrosis with myeloid metaplasia. 16091308 - Response inhibition and set shifting in patients with frontal lobe epilepsy or temporal... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
|
Title: Journal of atherosclerosis and thrombosis Volume: - ISSN: 1880-3873 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluating the long-term effect of FOBT in colorectal cancer screening.
Next Document: No Association of Diabetic Duration or Insulin Use with the Prognosis of Critical Limb Ischemia afte...