| Patients undergoing reconstructive surgery versus unburned children as "controls" in studies of pediatric patients with burns. | |
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MedLine Citation:
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PMID: 8582921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A valid control group is an essential part of any patient study. We asked whether burned children returning for reconstructive surgery could be used as "controls" in a study of seven proteolytic elements in the circulation. Functional levels of elastase, plasminogen, prekallikrein, antithrombin, alpha 2-antiplasmin, alpha 2-macroglobulin, and total proteolytic activity in 30 healthy unburned children were compared with levels in 29 patients admitted for reconstructive surgery an average of 7.9 years after burn. The two groups were not statistically different in distributions of sex and race but differed in mean age. Levels of six of the seven parameters were equal in the two groups. However, even when correction for the age difference was done between the groups, alpha 2-macroglobulin in the patients undergoing reconstructive surgery still was significantly less (p < 0.021) than in the unburned group. Therefore caution may be needed when readily available patients undergoing reconstructive surgery are used as "controls" in studies of patients with acute burns. |
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Authors:
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A N Neely; M T Rieman; G D Warden |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 16 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1995 Jul-Aug |
Date Detail:
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Created Date: 1996-03-20 Completed Date: 1996-03-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 418-21 Citation Subset: IM |
Affiliation:
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Shriners Burns Institute, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Analysis of Variance Antithrombin III / analysis Burns / enzymology, metabolism* Child Child, Preschool Controlled Clinical Trials as Topic Female Humans Male Pancreatic Elastase / analysis Peptide Hydrolases / analysis* Plasminogen / analysis Prekallikrein / analysis Reference Values Research Design Sensitivity and Specificity Surgery, Plastic alpha-2-Antiplasmin / analysis alpha-Macroglobulins / analysis |
| Chemical | |
Reg. No./Substance:
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0/alpha-2-Antiplasmin; 0/alpha-Macroglobulins; 9000-94-6/Antithrombin III; 9001-91-6/Plasminogen; 9055-02-1/Prekallikrein; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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