| Patients undergoing frozen-thawed embryo transfer have similar live birth rates in spontaneous and artificial cycles. | |
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MedLine Citation:
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PMID: 22391824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the outcome of frozen-thawed embryo transfer (FET) when freezing takes place at the pronuclear stage, a retrospective analysis was performed comparing spontaneous and artificial cycles. METHODS: 148 women received FET in a spontaneous cycle (Group A) and 55 women received FET in an artificial cycle (Group B) induced by administering estrogen (E2) and progesterone (P). Pregnancy rates, endometrial thickness and serum levels of E2, P and luteinizing hormone (LH) were measured. Statistical analysis included the mean, the standard deviation, the Chi-squared test and the T-test. RESULTS: The clinical pregnancy rate was 34.5% for Group A and 21.8% for Group B (p = 0.084), with a live birth rate of 20.9% and 12.7% respectively (p = 0.15). There was no difference in endometrial thickness or the P levels, while LH and E2 levels were significantly higher in group B (p < 0.0001). CONCLUSION: Our retrospective study shows a trend towards higher pregnancy rates and live birth rates with the administration of FET during a spontaneous cycle compared to FET during an artificial cycle. Large randomized controlled trials are needed to confirm this trend. |
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Authors:
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Katharina Hancke; Sabine More; Rolf Kreienberg; Jürgen M Weiss |
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Publication Detail:
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Type: Journal Article Date: 2012-03-03 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 29 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-09 Completed Date: 2012-11-08 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 403-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Ulm, Prittwitzstr. 43, 89075, Ulm, Germany. ka_hancke@yahoo.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Rate Embryo Transfer / methods* Endometrium / physiology Estrogens / blood Female Humans Live Birth / epidemiology* Luteinizing Hormone / blood Pregnancy Pregnancy Rate Progesterone / blood Reproductive Techniques, Assisted Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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