Document Detail

Patients undergoing frozen-thawed embryo transfer have similar live birth rates in spontaneous and artificial cycles.
MedLine Citation:
PMID:  22391824     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the outcome of frozen-thawed embryo transfer (FET) when freezing takes place at the pronuclear stage, a retrospective analysis was performed comparing spontaneous and artificial cycles.
METHODS: 148 women received FET in a spontaneous cycle (Group A) and 55 women received FET in an artificial cycle (Group B) induced by administering estrogen (E2) and progesterone (P). Pregnancy rates, endometrial thickness and serum levels of E2, P and luteinizing hormone (LH) were measured. Statistical analysis included the mean, the standard deviation, the Chi-squared test and the T-test.
RESULTS: The clinical pregnancy rate was 34.5% for Group A and 21.8% for Group B (p = 0.084), with a live birth rate of 20.9% and 12.7% respectively (p = 0.15). There was no difference in endometrial thickness or the P levels, while LH and E2 levels were significantly higher in group B (p < 0.0001).
CONCLUSION: Our retrospective study shows a trend towards higher pregnancy rates and live birth rates with the administration of FET during a spontaneous cycle compared to FET during an artificial cycle. Large randomized controlled trials are needed to confirm this trend.
Katharina Hancke; Sabine More; Rolf Kreienberg; Jürgen M Weiss
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Publication Detail:
Type:  Journal Article     Date:  2012-03-03
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-09     Completed Date:  2012-11-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Ulm, Prittwitzstr. 43, 89075, Ulm, Germany.
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MeSH Terms
Birth Rate
Embryo Transfer / methods*
Endometrium / physiology
Estrogens / blood
Live Birth / epidemiology*
Luteinizing Hormone / blood
Pregnancy Rate
Progesterone / blood
Reproductive Techniques, Assisted
Retrospective Studies
Reg. No./Substance:
0/Estrogens; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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