Document Detail

Patients' obstetric history in mid-trimester termination of pregnancy with gemeprost: does it really matter?
MedLine Citation:
PMID:  16309822     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective was to investigate the importance of previous obstetric history for termination of pregnancy in the second-trimester with gemeprost alone. STUDY DESIGN: A consecutive series of 423 mid-trimester inductions of abortion at our teaching hospital was reviewed. Termination of pregnancy was carried out with 1mg of vaginal gemeprost every 3h up to three doses over a 24-h period, repeated the following day if necessary. Failed induction was defined as women undelivered by 96 h. The study population was then stratified by gestational age, parity, gravidity and previous uterine scars. Main outcome parameters were failed induction and complication rates. Statistical analysis was performed using the chi(2) test or Fisher's exact test for categorical data, and the t-test and linear regression for continuous variables. RESULTS: No significant differences were found in the primary outcome parameters with regard to the obstetric parameters considered. The failed induction rate was 1.2% with an overall incidence of complications of 7.4%. Parity was the main factor that affected clinical response (time to abortion interval and number of pessaries). CONCLUSION: Patients' obstetric history does affect the clinical response to gemeprost, but its safety and effectiveness are preserved. These data provide clinicians with important information for correct counselling.
Marco Scioscia; Antonella Vimercati; Giovanni Pontrelli; Luigi Nappi; Luigi Selvaggi
Publication Detail:
Type:  Journal Article     Date:  2005-11-23
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  130     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Bari, Policlinico di Bari, Piazza Giulio Cesare 11, 70125 Bari, Italy.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / adverse effects*
Abortion, Induced / adverse effects*
Administration, Intravaginal
Alprostadil / adverse effects,  analogs & derivatives*
Gestational Age
Pregnancy Trimester, First / drug effects
Pregnancy Trimester, Second / drug effects
Retrospective Studies
Risk Factors
Uterus / abnormalities
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 64318-79-2/gemeprost; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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