| A Patient with Postpartum Hypopituitarism (Sheehan's Syndrome) Developed Postpartum Autoimmune Thyroiditis (Transient Thyrotoxicosis and Hypothyroidism): A Case Report and Review of the Literature. | |
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MedLine Citation:
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PMID: 21603170 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A 36-year-old woman with postpartum hypopituitarism (Sheehan's syndrome: SS) developed postpartum autoimmune thyroiditis (PPAT). She delivered a baby by Caesarean section (620 mL blood loss). At 1 month post partum, she developed thyrotoxicosis due to painless thyroiditis (autoimmune destructive thyroiditis). She was positive for antithyroid antibodies. Postpartum and hypoadrenalism-induced exacerbation of autoimmune thyroiditis caused the thyrotoxicosis due to autoimmune destructive thyroiditis. ACTH was undetectable. She had ACTH deficiency and secondary hypoadrenalism. Hydrocortisone was started. At 6 months post partum, she was referred to us with hypothyroidism. Thyroxine was administered. She had thyrotoxicosis at 1-2 months post partum and then hypothyroidism. She was diagnosed with PPAT. She had hypopituitarism, ACTH deficiency (secondary hypoadrenalism), low prolactin with agalactia, and low LH with failure to resume regular menses. She had empty sella on MRI. She was diagnosed with SS. Three cases with SS have been reported to develop PPAT. Postpartum immunological rebounds and hypoadrenalism-induced immunological alterations (or a combination of the two) might have been responsible for the PPAT. |
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Authors:
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Nobuyuki Takasu; Yoshirou Nakayama |
Publication Detail:
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Type: Journal Article Date: 2011-04-11 |
Journal Detail:
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Title: Journal of thyroid research Volume: 2011 ISSN: 2042-0072 ISO Abbreviation: J Thyroid Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101536655 Medline TA: J Thyroid Res Country: United States |
Other Details:
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Languages: eng Pagination: 413026 Citation Subset: - |
Affiliation:
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Department of Endocrinology and Metabolism, Aizawa Hospital, 2-5-1 Honjo, Mtasumoto 390-8521, Japan. |
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