| Patient survival and safety with biologic therapy. Results of the Mexican National Registry Biobadamex 1.0. | |
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MedLine Citation:
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PMID: 22673388 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This work reports patient treatment survival and adverse events related to Biologic Therapy (BT), identified by a multicenter ambispective registry of 2047 rheumatic patients undergoing BT and including a control group of Rheumatoid Arthritis (RA) patients not using BT. The most common diagnoses were: RA 79.09%, Ankylosing Spondilytis 7.96%, Psoriatic Arthritis 4.40%, Systemic Lupus Erythematosus 3.37%, Juvenile Idiopathic Arthritis 1.17%. A secondary analysis included 1514 cases from the total sample and was performed calculating an incidence rate of any adverse events of 178 × 1000/ BT patients per year vs. 1009 x 1000/control group patients per year with a 1.6 RR (IC95% 1.4-1.9). For serious adverse events the RR was: 15.4 (95% CI 3.7-63.0, P<.0001). Global BT survival was 80% at 12 months, 61% at 24 months, 52% at 36 months and 45% at 48 months. SMR: 0.23 (95%CI 0.0-49.0) for BT vs. 0.00 (95%CI 0.0-0.2) for the control group. In conclusion, BT was associated to a higher infection risk and adverse events, compared to other patients. Mortality using BT was not higher than expected for general population with same gender and age. |
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Authors:
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Lucio Ventura-Ríos; David Bañuelos-Ramírez; María Del Carmen Hernández-Quiroz; Manuel Robles-San Román; Fedra Irazoque-Palazuelos; María Victoria Goycochea-Robles |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-4 |
Journal Detail:
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Title: Reumatologia clinica Volume: - ISSN: 1885-1398 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101293923 Medline TA: Reumatol Clin Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier España, S.L. All rights reserved. |
Affiliation:
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Consulta de Reumatología, Hospital Central Sur PEMEX, México DF, México. |
Vernacular Title:
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Terapia biológica: sobrevida y seguridad en padecimientos reumáticos. Resultados del Registro Nacional Biobadamex 1.0. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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