| Patient state index vs bispectral index as measures of the electroencephalographic effects of propofol. | |
| | |
MedLine Citation:
|
PMID: 20587537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The patient state index (PSI) and the bispectral index (BIS) quantify anaesthetic depth based on the EEG using different algorithms. We compared both indices with regard to the prediction of the depth of propofol anaesthesia. METHODS: In 17 patients, propofol was infused until burst suppression occurred and stopped thereafter until BIS recovered to values above 60. This was repeated; afterwards, patients were intubated, for subsequent surgery. Without surgical stimulus, PSI and BIS were measured simultaneously and compared with the estimated effect-site concentrations of propofol. These were derived from simultaneous pharmacokinetic and -dynamic modelling in an individual two-stage and a population-based NONMEM approach. RESULTS: A close sigmoid relationship was observed between the propofol effect-site concentration and both PSI [coefficient of determination rho(2)=0.91 (sd 0.05)] and BIS [rho(2)=0.92 (0.03)], which was significantly steeper for PSI [gamma=2.2 (0.6)] than for BIS [gamma=1.8 (0.4)], and reached significantly lower values for PSI [E(max)=0.3 (1.1)] than for BIS [E(max)=5.3 (6.7)] at maximal propofol concentrations. A significantly smaller k(e0) was obtained for PSI [0.09 (0.03) min(-1)] compared with BIS [0.10 (0.02) min(-1)]. PSI and BIS correlated significantly with each other (rho(2)=0.866) and predicted propofol effect-site concentration with a comparable probability [P(K)=0.87 (0.05) and 0.86 (0.05), respectively]. NONMEM revealed E(0)=89.3 and 92.3, E(max)=1.9 and 8.6, C(e50)=1.38 and 1.92 microg ml(-1), gamma=1.6 and 1.48, and k(e0)=0.103 and 0.131 min(-1) as typical values for PSI and BIS, respectively. CONCLUSIONS: The PSI and the BIS monitors performed equally well in predicting depth of propofol anaesthesia. However, PSI was lower than BIS by approximately 10-15 points at high propofol concentrations. |
| | |
Authors:
|
M Soehle; M Kuech; M Grube; S Wirz; S Kreuer; A Hoeft; J Bruhn; R K Ellerkmann |
Related Documents
:
|
18607947 - Efficacy of total intravenous anesthesia without intubation for laryngeal framework sur... 1809047 - Reversal of central benzodiazepine effects by intravenous flumazenil. 19713257 - The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniot... 14517657 - Multiple-deep-breath inhalation induction with 5% sevoflurane and 67% nitrous oxide: co... 10759967 - Experience with low-dose thalidomide therapy in chronic discoid lupus erythematosus. 17552007 - Long-term results of subtotal colectomy with cecorectal anastomosis for isolated coloni... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-29 |
Journal Detail:
|
Title: British journal of anaesthesia Volume: 105 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-14 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
|
Languages: eng Pagination: 172-8 Citation Subset: IM |
Affiliation:
|
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany. martin.soehle@ukb.uni-bonn.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Anesthetics, Intravenous / administration & dosage, blood, pharmacology* Dose-Response Relationship, Drug Electroencephalography / drug effects* Female Humans Male Middle Aged Monitoring, Intraoperative / methods* Otorhinolaryngologic Surgical Procedures Propofol / administration & dosage, blood, pharmacology* Reproducibility of Results Signal Processing, Computer-Assisted* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Intravenous; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades o...
Next Document: Saving the patient the radiation: no need for ECG-gating during cardiac computed tomography.