Document Detail

Patient specific identification of the cardiac driver function in a cardiovascular system model.
MedLine Citation:
PMID:  20621383     Owner:  NLM     Status:  In-Data-Review    
The cardiac muscle activation or driver function, is a major determinant of cardiovascular dynamics, and is often approximated by the ratio of the left ventricle pressure to the left ventricle volume. In an intensive care unit, the left ventricle pressure is usually never measured, and the left ventricle volume is only measured occasionally by echocardiography, so is not available real-time. This paper develops a method for identifying the driver function based on correlates with geometrical features in the aortic pressure waveform. The method is included in an overall cardiovascular modelling approach, and is clinically validated on a porcine model of pulmonary embolism. For validation a comparison is done between the optimized parameters for a baseline model, which uses the direct measurements of the left ventricle pressure and volume, and the optimized parameters from the approximated driver function. The parameters do not significantly change between the two approaches thus showing that the patient specific approach to identifying the driver function is valid, and has potential clinically.
C E Hann; J Revie; D Stevenson; S Heldmann; T Desaive; C B Froissart; B Lambermont; A Ghuysen; P Kolh; G M Shaw; J G Chase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  101     ISSN:  1872-7565     ISO Abbreviation:  Comput Methods Programs Biomed     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Christchurch 8020, New Zealand.
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