Document Detail

Patient-reported complications from fiducial marker implantation for prostate image-guided radiotherapy.
MedLine Citation:
PMID:  22253345     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To report on complications from transrectal ultrasound-guided insertion of fiducial markers for prostate image-guided radiotherapy.
METHODS: 234 patients who underwent transrectal fiducial marker insertion for prostate cancer image-guided radiotherapy were assessed retrospectively by questionnaire with regard to the duration and severity of eight symptoms experienced following the procedure. Pain during the implantation procedure was assessed according to the Wong-Baker faces pain scale.
RESULTS: Of 234 patients, 32% had at least one new symptom after the procedure. The commonest new symptom following the procedure was urinary frequency affecting 16% of patients who had not been troubled by frequency beforehand. Haematuria, rectal bleeding, dysuria and haematospermia affected 9-13% of patients, mostly at Grade 1 or 2. Pain, obstruction, and fever and shivers affected 3-4% of patients. Grade 3 rectal bleeding, haematuria, fever and shivers, and urinary frequency affected 0.5-1.5% of patients. Only one patient had a Grade 4 complication (i.e. fever and shivers). Overall, 9% of patients had symptoms lasting more than 2 weeks. The commonest symptoms that lasted more than 2 weeks were frequency, dysuria, obstructive symptoms and rectal bleeding. Mean pain score during the procedure was 1.1 (range 0-5).
CONCLUSION: Transrectal ultrasound-guided fiducial marker insertion for image-guided radiotherapy is well tolerated in the majority of prostate cancer patients. Most symptoms were Grade 1 or 2 in severity. Symptoms in the majority of patients last under 2 weeks. The most serious complication was sepsis in our study.
S Gill; J Li; J Thomas; M Bressel; K Thursky; C Styles; K H Tai; G M Duchesne; F Foroudi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-17
Journal Detail:
Title:  The British journal of radiology     Volume:  85     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-09-12     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1011-7     Citation Subset:  AIM; IM    
Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
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MeSH Terms
Aged, 80 and over
Fever / epidemiology,  etiology,  physiopathology
Fiducial Markers / adverse effects*
Follow-Up Studies
Hematuria / epidemiology,  etiology,  physiopathology
Middle Aged
Pain / epidemiology,  etiology,  physiopathology
Pain Measurement
Prostatic Neoplasms / pathology,  radiotherapy*
Radiotherapy, Image-Guided / adverse effects,  methods*
Retrospective Studies
Risk Assessment
Ultrasonography, Interventional / methods
Urinary Tract Infections / epidemiology,  etiology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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