Document Detail

Patient related factors leading to slow urea transfer in the body during dialysis.
MedLine Citation:
PMID:  8003753     Owner:  NLM     Status:  MEDLINE    
We studied the trans compartmental speed of urea transfer by comparing concentration changes of blood urea nitrogen to mass changes of urea during 80 dialyses in six patients. The speed of urea transfer was studied as a dependent factor of 15 patient characteristics: age; gender; fluid overload; and pre and post values of and change in pulse and temperature, calcitonin gene related peptide, and mean arterial blood pressure. Concentration changes in blood urea nitrogen were measured as pre and post dialysis urea concentration, the total urea in the body was measured by pre dialysis urea and tritium total body water determinations, and the actual mass of urea removed by collecting all dialysate. As a mean, concentration of blood urea nitrogen fell 54% but the mass urea removed was only 40% for a mean ratio of 1.41. Nine factors were associated with the speed of urea transfer. Patients with fast transfer had more normal fluid balance, a normal pulse rate, body temperature, calcitonin gene related peptide values, and blood pressure both before and after dialysis. The patients with a slower transfer of urea had a lower blood pressure before and after dialysis and a more labile pulse rate and body temperature. Patients with unpredictable urea transfer were the most edematous and had the most labile blood pressure. It is important to know which patients have slow urea transfer. Such patients should not be treated by fast dialysis, and those with the slowest rates may do particularly well on continuous ambulatory peritoneal dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
C Kjellstrand; R Skröder; I O Cederlöf; F Ericsson; P Kjellstrand; S Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  40     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1994 Apr-Jun
Date Detail:
Created Date:  1994-07-18     Completed Date:  1994-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-70     Citation Subset:  IM    
Department of Medicine, University of Alberta, Faculty of Medicine, Edmonton, Canada.
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MeSH Terms
Aged, 80 and over
Blood Urea Nitrogen
Body Water / chemistry
Middle Aged
Predictive Value of Tests
Renal Dialysis*
Urea / metabolism*
Reg. No./Substance:

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