| Patient reactions to personalized medicine vignettes: an experimental design. | |
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MedLine Citation:
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PMID: 21270639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Translational investigation on personalized medicine is in its infancy. Exploratory studies reveal attitudinal barriers to "race-based medicine" and cautious optimism regarding genetically personalized medicine. This study describes patient responses to hypothetical conventional, race-based, or genetically personalized medicine prescriptions. METHODS: Three hundred eighty-seven participants (mean age = 47 years; 46% white) recruited from a Baltimore outpatient center were randomized to this vignette-based experimental study. They were asked to imagine a doctor diagnosing a condition and prescribing them one of three medications. The outcomes are emotional response to vignette, belief in vignette medication efficacy, experience of respect, trust in the vignette physician, and adherence intention. RESULTS: Race-based medicine vignettes were appraised more negatively than conventional vignettes across the board (Cohen's d = -0.51-0.57-0.64, P < 0.001). Participants rated genetically personalized comparably with conventional medicine (-0.14-0.15-0.17, P = 0.47), with the exception of reduced adherence intention to genetically personalized medicine (Cohen's d = -0.38-0.41-0.44, P = 0.009). This relative reluctance to take genetically personalized medicine was pronounced for racial minorities (Cohen's d = -0.38-0.31-0.25, P = 0.02) and was related to trust in the vignette physician (change in R = 0.23, P < 0.001). CONCLUSIONS: This study demonstrates a relative reluctance to embrace personalized medicine technology, especially among racial minorities, and highlights enhancement of adherence through improved doctor- patient relationships. |
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Authors:
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Morgan Butrick; Debra Roter; Kimberly Kaphingst; Lori H Erby; Carlton Haywood; Mary Catherine Beach; Howard P Levy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Genetics in medicine : official journal of the American College of Medical Genetics Volume: 13 ISSN: 1530-0366 ISO Abbreviation: Genet. Med. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-10 Completed Date: 2011-08-25 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9815831 Medline TA: Genet Med Country: United States |
Other Details:
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Languages: eng Pagination: 421-8 Citation Subset: IM |
Affiliation:
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Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21202, USA. mbutrick@jhsph.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Continental Population Groups / psychology Female Health Knowledge, Attitudes, Practice* Humans Individualized Medicine / psychology* Male Middle Aged Patient Acceptance of Health Care / psychology Physician-Patient Relations Research Design* Trust / psychology |
| Grant Support | |
ID/Acronym/Agency:
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L60 MD000303-01/MD/NIMHD NIH HHS; L60 MD000303-02/MD/NIMHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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