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Patient-maintained propofol sedation using reaction time monitoring: a volunteer safety study*
MedLine Citation:
PMID:  23153106     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Previous volunteer studies of an effect-site controlled, patient-maintained sedation system using propofol have demonstrated a risk of over-sedation. We have incorporated a reaction-time monitor into the handset of the patient-maintained sedation system to add an individualised patient-feedback mechanism. This study assessed if such reaction-time feedback modification would reduce the risk of over-sedation in 20 healthy volunteers deliberately attempting to over-administer themselves propofol. All the volunteers successfully sedated themselves without reaching any unsafe endpoints. All volunteers maintained verbal contact throughout, in accordance with the definition of conscious sedation. The mean (SD) lowest S(p) O(2) was 97 (1.7) % when breathing room air and no volunteer required supplementary oxygen. The mean (SD) maximum effect-site propofol concentration reached was 1.7 (0.4) μg.ml(-1) . The present system was found to be safer than its predecessors, allowing conscious sedation, but preventing over-sedation.
Authors:
S Allam; K J Anderson; C O'Brien; J A Macpherson; S Gambhir; J A Leitch; G N C Kenny
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  Anaesthesia     Volume:  -     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
Affiliation:
 Consultant, Department of Anaesthesia, Forth Valley Royal Hospital, Larbert, UK  Assistant Clinical Professor Department of Anaesthesia, Foothills Medical Centre, Calgary, Canada  Associate Specialist in Oral Surgery, University of Glasgow Dental School, Glasgow, UK  Consultant in Special Care Dentistry, Liverpool University Dental Hospital, Liverpool, UK  Consultant Anaesthetist, Hairmyres Hospital, East Kilbride, UK  Clinical Director, Quality Unit, Scottish Government, Edinburgh, UK  Emeritus Professor, University of Glasgow Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, UK.
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