Document Detail

Patient-maintained propofol sedation: a follow up safety study using a modified system in volunteers.
MedLine Citation:
PMID:  11949642     Owner:  NLM     Status:  MEDLINE    
Patient-maintained sedation is a mode of patient-controlled sedation during which propofol is administered using a target-controlled infusion, with patient demand increasing the target concentration. A system tested previously for safety in our institution resulted in oversedation. Aiming to improve safety, we modified the system by increasing the lockout period to 4 min,reducing the starting concentration to 0.5 microg x ml(-1) and the increments on demand to 0.1 microg x ml(-1). As in the previous study, healthy volunteers attempted to render themselves unconscious by frequently pressing the demand button. To assess effects on memory, volunteers were given keywords to remember every 15 min. The maximum target concentration reached varied between 1.0 and 2.5 microg x ml(-1). No volunteers lost consciousness, however, one volunteer had a brief period of apnoea and oxygen desaturation. The Cp50 for loss of memory for words was 1.26 microg x ml(-1). Although this version represents an improvement, we conclude that the system is not yet completely suitable for use without anaesthetic supervision.
F Henderson; A R Absalom; G N C Kenny
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  57     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  387-90     Citation Subset:  AIM; IM    
Department of Anaesthesia, Western Infirmary, Glasgow, UK.
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MeSH Terms
Apnea / chemically induced
Conscious Sedation / adverse effects,  methods*
Drug Administration Schedule
Follow-Up Studies
Hypnotics and Sedatives / administration & dosage*,  blood
Infusion Pumps
Memory / drug effects
Middle Aged
Propofol / administration & dosage*,  blood
Self Administration
Reg. No./Substance:
0/Hypnotics and Sedatives; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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