Document Detail

Patient controlled analgesia for labour: a comparison of remifentanil with pethidine.
MedLine Citation:
PMID:  15601268     Owner:  NLM     Status:  MEDLINE    
We compared the analgesic efficacy and safety of remifentanil and pethidine via patient controlled analgesia for women in established uncomplicated labour. Women received either remifentanil 40 microg with a 2-min lockout (n = 20) or pethidine 15 mg with a 10-min lockout (n = 19). Visual analogue scores for pain during the study and for overall pain were similar for both groups (mean (SD) 6.4 (1.5) cm for remifentanil and 6.9 (1.7) cm for pethidine). The area under the curve for visual analogue scores of satisfaction with analgesia was higher for remifentanil than for pethidine (p = 0.001). Maternal arterial oxygen saturation was similar in both groups. Neurologic and Adaptive Capacity Scores at 30 min were higher for remifentanil than for pethidine (median (interquartile range [range]) 36 (34.5-37 [32-39]) vs 34 (33-35 [30-35]), respectively; p = 0.003).
J M Blair; G T Dobson; D A Hill; G R McCracken; J P H Fee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2005-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  AIM; IM    
St. Helier Hospital, Epsom and St. Helier University Hospitals NHS Trust, Wrythe Lane, Carshalton, Surrey SM5 1AA, UK.
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MeSH Terms
Analgesia, Obstetrical / methods*
Analgesia, Patient-Controlled / methods*
Analgesics, Opioid*
Double-Blind Method
Oxygen / blood
Pain Measurement / methods
Partial Pressure
Patient Satisfaction
Pregnancy Outcome
Reg. No./Substance:
0/Analgesics, Opioid; 0/Piperidines; 132875-61-7/remifentanil; 57-42-1/Meperidine; 7782-44-7/Oxygen
Comment In:
Anaesthesia. 2005 Dec;60(12):1244   [PMID:  16288630 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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