Document Detail

Patient State Index (PSI) measures depth of sedation in intensive care patients.
MedLine Citation:
PMID:  14673519     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether the electroencephalogram (EEG)-based Patient State Index (PSI) indicates the level of sedation as measured by Ramsay score in intubated and mechanically ventilated patients in the ICU. DESIGN: Prospective, single-blinded observer study. SETTING: Surgical intensive care unit. PATIENTS: Forty-one consecutive adult patients requiring intubation and ventilation during intensive care therapy. MEASUREMENTS AND RESULTS: Following skin preparation with alcohol and placement of EEG electrodes, PSI was recorded while patients were ventilated and sedated with constant drug infusion rates. After 30 min, the level of sedation was measured by an assessor, who was blinded to PSI values, using the Ramsay sedation score. For analysis, the mean of PSI values measured during the last minute before clinical assessment of sedation was calculated. General Linear Model (GLM) analysis revealed significant differences between the PSI values at different levels of sedation as measured by the Ramsay score, except for the differentiation of level 5 from levels 4 and 6 (p>0.3) and level 2 from level 3, where only a trend was reached (p=0.077). The prediction probability of PSI was 0.920+/-0.037. CONCLUSION: As the high prediction probability and the analysis of paired comparisons suggest, PSI may be used to quantify the level of propofol/sufentanil sedation in ICU patients. Further studies are required to test whether these promising results can be verified for other drug combinations.
Gerhard Schneider; Susanne Heglmeier; Jürgen Schneider; Gunter Tempel; Eberhard F Kochs
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-12-12
Journal Detail:
Title:  Intensive care medicine     Volume:  30     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-6     Citation Subset:  IM    
Department of Anaesthesiology, Technische Universität München, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany.
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MeSH Terms
Aged, 80 and over
Drug Monitoring
Electroencephalography / methods
Hypnotics and Sedatives / administration & dosage*
Intensive Care*
Intensive Care Units
Middle Aged
Monitoring, Physiologic*
Prospective Studies
Single-Blind Method
Reg. No./Substance:
0/Hypnotics and Sedatives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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