Document Detail


Patient perceptions of fecal microbiota transplantation for ulcerative colitis.
MedLine Citation:
PMID:  23624888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fecal microbiota transplantation (FMT), the delivery of stool from a healthy prescreened donor to an individual with disease, is gaining increasing recognition as a potential treatment for inflammatory bowel diseases. Our objective was to describe patient interest in and social concerns around FMT.
METHODS: We conducted a survey of adults with ulcerative colitis (UC) seen in outpatient clinic at the University of Chicago IBD Center. All English-speaking patients ≥18 years of age were eligible. Subjects completed a written survey in clinic. Ninety-five participants, median age 39 years, 53% female, were enrolled in the study.
RESULTS: Forty-four percent and 49% reported excellent or good/satisfactory medical management of their UC, respectively. Forty-six percent participants were willing to undergo FMT as a treatment of UC, 43% were unsure, and 11% were unwilling to undergo FMT. Subjects who had been hospitalized were more willing to undergo FMT, 54% versus 34%, P = 0.035. Primary concerns included the following: adequate screening for infections (41%), cleanliness (24%), and potential to worsen UC (18%); 21% reported no specific concerns. For donor selection, an equal number of participants (46%) preferred whomever their doctor recommended or family member/spouse.
CONCLUSIONS: In our center despite reporting satisfactory to excellent disease control with their treatments, the vast majority of patients with UC are interested in or willing to consider FMT. Proof of safety and effectiveness, and failure of other medical therapies are key issues in considering FMT. Strong interest in this as-yet unproven therapy warrants attention and is a pressing priority for clinical research and education.
Authors:
Stacy A Kahn; Ashley Vachon; Dylan Rodriquez; Sarah R Goeppinger; Bonnie Surma; Julia Marks; David T Rubin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  19     ISSN:  1536-4844     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-27     Completed Date:  2014-01-22     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1506-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Therapy / methods*
Colitis, Ulcerative / microbiology,  psychology,  therapy*
Feces / microbiology*
Female
Follow-Up Studies
Health Knowledge, Attitudes, Practice
Humans
Male
Microbiota*
Middle Aged
Perception*
Prognosis
Transplantation*
Young Adult
Grant Support
ID/Acronym/Agency:
KL2TR000431/TR/NCATS NIH HHS; P30 DK042086/DK/NIDDK NIH HHS; UL1 RR024999/RR/NCRR NIH HHS
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