Document Detail

Patient activation and improved outcomes in HIV-infected patients.
MedLine Citation:
PMID:  23288378     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Patient Activation Measure (PAM) assesses several important concepts in chronic care management, including self-efficacy for positive health behaviors. In HIV-infected populations, better self-efficacy for medication management is associated with improved adherence to antiretroviral medications (ARVs), which is critically important for controlling symptoms and slowing disease progression.
OBJECTIVE: To determine 1) characteristics associated with patient activation and 2) associations between patient activation and outcomes in HIV-infected patients.
DESIGN: Cross-sectional survey.
PARTICIPANTS: 433 patients receiving care in four HIV clinics.
METHODS: An interviewer conducted face-to-face interviews with patients following their HIV clinic visit. Survey data were supplemented with medical record abstraction to obtain most recent CD4 counts, HIV viral load and antiretroviral medications.
MAIN MEASURES: Patient activation was measured using the 13-item PAM (possible range 0-100). Outcomes included CD4 cell count > 200 cells/mL(3), HIV-1 RNA < 400 copies/mL (viral suppression), and patient-reported adherence.
KEY RESULTS: Overall, patient activation was high (mean PAM = 72.3 [SD 16.5, range 34.7-100]). Activation was lower among those without vs. with a high school degree (68.0 vs. 74.0, p < .001), and greater depression (77.6 lowest, 70.2 middle, 68.1 highest tertile, p < .001). There was no association between patient activation and age, race, gender, problematic alcohol use, illicit drug use, or social status. In multivariable models, every 5-point increase in PAM was associated with greater odds of CD4 count > 200 cells/mL(3) (aOR 1.10 [95 % CI 1.01, 1.21]), adherence (aOR 1.18 [95 % CI 1.09, 1.29]) and viral suppression (aOR 1.08 [95 % CI 1.00, 1.17]). The association between PAM and viral suppression was mediated through adherence.
CONCLUSIONS: Higher patient activation was associated with more favorable HIV outcomes. Interventions to improve patient activation should be developed and tested for their ability to improve HIV outcomes.
Rebecca Marshall; Mary Catherine Beach; Somnath Saha; Tomi Mori; Mark O Loveless; Judith H Hibbard; Jonathan A Cohn; Victoria L Sharp; P Todd Korthuis
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of general internal medicine     Volume:  28     ISSN:  1525-1497     ISO Abbreviation:  J Gen Intern Med     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-11-22     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8605834     Medline TA:  J Gen Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  668-74     Citation Subset:  IM    
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MeSH Terms
Anti-HIV Agents / therapeutic use
CD4 Lymphocyte Count
Cross-Sectional Studies
HIV Infections / drug therapy*,  psychology,  virology
HIV-1 / isolation & purification*
Health Behavior
Medication Adherence / psychology,  statistics & numerical data
Middle Aged
Self Care / standards*
Self Efficacy*
Treatment Outcome
Viral Load
Young Adult
Grant Support
Reg. No./Substance:
0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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