Document Detail

Pathways for the synthesis of sorbitol from 13C-labeled hexoses, pentose, and glycerol in renal papillary tissue.
MedLine Citation:
PMID:  2496284     Owner:  NLM     Status:  MEDLINE    
Suspensions of rabbit renal papillary tissue were incubated with D-[6-13C]glucose, D-[1-13C]fructose, D-[1-13C]ribose, and [2-13C]glycerol. The perchloric acid extracts of the above incubations were investigated with 13C NMR spectroscopy. All 13C-labeled substrates give rise to 13C-labeled D-sorbitol. D-[6-13C]Glucose and D-[1-13C]fructose are converted directly into D-sorbitol via the aldose reductase and sorbitol dehydrogenase pathway, respectively, whereas D-[1-13C]ribose and [2-13C]glycerol give rise to labeling of the D-glyceraldehyde pool which on its turn causes a labeling of D-sorbitol. Label exchanges observed from incubations with glycerol and D-ribose indicate that the pentose shunt plays a role in this synthesis of D-sorbitol.
A W Jans; R W Grunewald; R K Kinne
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  9     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-08     Completed Date:  1989-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-22     Citation Subset:  IM    
Max-Planck-Institut fuer Systemphysiologie, Dortmund, Federal Republic of Germany.
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MeSH Terms
Glucose / metabolism*
Glycerol / metabolism*
Kidney Medulla / metabolism*
L-Iditol 2-Dehydrogenase / metabolism
Magnetic Resonance Spectroscopy
Pentose Phosphate Pathway
Ribose / metabolism*
Sorbitol / biosynthesis*
Reg. No./Substance:
50-69-1/Ribose; 50-70-4/Sorbitol; 50-99-7/Glucose; 56-81-5/Glycerol; EC 2-Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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