|Pathways of protein secretion in eukaryotes.|
|PMID: 2994224 Owner: NLM Status: MEDLINE|
|Protein secretion from cells can take several forms. Secretion is constitutive if proteins are secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins destined for secretion are stored at high concentration in secretory vesicles until the cell receives an appropriate stimulus. When both constitutive and regulated protein secretion can take place in the same cell a mechanism must exist for sorting the correct secretory protein into the correct secretory vesicle. The secretory vesicle must then be delivered to the appropriate region of plasma membrane. Transfection of DNA encoding foreign secretory proteins into regulated secretory cells has provided insight into the specificity of sorting into secretory vesicles.|
|R B Kelly|
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|Type: Journal Article|
|Title: Science (New York, N.Y.) Volume: 230 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1985 Oct|
|Created Date: 1985-10-22 Completed Date: 1985-10-22 Revised Date: 2007-03-19|
Medline Journal Info:
|Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES|
|Languages: eng Pagination: 25-32 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Calcium / metabolism
Calmodulin / metabolism
Carrier Proteins / physiology
Cells / secretion*
Cytoplasmic Granules / metabolism
Eukaryotic Cells / cytology, secretion*
Golgi Apparatus / ultrastructure
Leukemia Virus, Murine / genetics
Lysosomes / enzymology
Membrane Proteins / genetics, metabolism
Peptide Hydrolases / metabolism
Pituitary Gland / cytology
Pro-Opiomelanocortin / secretion
Proteins / secretion*
|0/Calmodulin; 0/Carrier Proteins; 0/Membrane Proteins; 0/Proteins; 66796-54-1/Pro-Opiomelanocortin; 7440-70-2/Calcium; 9002-60-2/Adrenocorticotropic Hormone; EC 3.4.-/Peptide Hydrolases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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