| Pathways in pulmonary arterial hypertension: the future is here. | |
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MedLine Citation:
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PMID: 23204120 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It is well established that the endothelin, nitric oxide and prostacyclin pathways play an important role in the development of pulmonary arterial hypertension (PAH). Indeed, the therapeutic options currently available for the management of PAH all act on one of these mechanistic pathways. However, this is an exciting time for both clinicians and scientists, as increased understanding of the mechanisms involved in the pathogenesis and progression of PAH has resulted in the development of a number of novel therapeutic options. This article highlights how the introduction of new compounds such as macitentan, riociguat and selexipag, which act on the endothelin, nitric oxide and prostacyclin pathways, respectively, have the potential to further improve the prognosis for patients with PAH. |
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Authors:
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Olivier Sitbon; Nicholasw Morrell |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European respiratory review : an official journal of the European Respiratory Society Volume: 21 ISSN: 1600-0617 ISO Abbreviation: Eur Respir Rev Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111391 Medline TA: Eur Respir Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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Université Paris-Sud, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. # Dept of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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