| Pathways and control of connexin oligomerization. | |
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MedLine Citation:
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PMID: 16490353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Connexins form gap junction channels that link neighboring cells into an intercellular communication network. Many cells that express multiple connexins produce heteromeric channels containing at least two connexins, which provides a means to fine tune gap junctional communication. Formation of channels by multiple connexins is controlled at two levels: by inherent structural compatibilities that enable connexins to hetero-oligomerize and by cellular mechanisms that restrict the formation of heteromers by otherwise compatible connexins. Here, I discuss roles for secretory compartments beyond the endoplasmic reticulum in connexin oligomerization and evidence that suggests that membrane microdomains help regulate connexin trafficking and assembly. |
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Authors:
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Michael Koval |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-02-21 |
Journal Detail:
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Title: Trends in cell biology Volume: 16 ISSN: 0962-8924 ISO Abbreviation: Trends Cell Biol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-13 Completed Date: 2006-07-19 Revised Date: 2010-08-09 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 159-66 Citation Subset: IM |
Affiliation:
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Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. mhkoval@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication Connexins / chemistry, genetics, metabolism* Endoplasmic Reticulum Gap Junctions / chemistry*, metabolism* Lysine / metabolism Membrane Microdomains / metabolism, physiology* Models, Molecular Models, Theoretical Molecular Probe Techniques Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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GM 61012/GM/NIGMS NIH HHS; P01 HL 019737-26/HL/NHLBI NIH HHS; P01 HL019737-300018/HL/NHLBI NIH HHS; R01 GM061012-06/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Connexins; 56-87-1/Lysine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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