| Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex. | |
| | |
MedLine Citation:
|
PMID: 19337274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Functional neuroimaging signals are generated, in part, by increases in cerebral blood flow (CBF) evoked by mediators, such as nitric oxide and arachidonic acid derivatives that are released in response to increased neurotransmission. However, it is unknown whether the vascular and metabolic responses within a given brain area differ when local neuronal activity is evoked by an activity in the distinct neuronal networks. In this study we assessed, for the first time, the differences in neuronal responses and changes in CBF and oxygen consumption that are evoked after the activation of two different inputs to a single cortical area. We show that, for a given level of glutamatergic synaptic activity, corticocortical and thalamocortical inputs evoked activity in pyramidal cells and different classes of interneurons, and produced different changes in oxygen consumption and CBF. Furthermore, increases in stimulation intensities either turned off or activated additional classes of inhibitory interneurons immunoreactive for different vasoactive molecules, which may contribute to increases in CBF. Our data imply that for a given cortical area, the amplitude of vascular signals will depend critically on the type of input, and that a positive blood oxygen level-dependent (BOLD) signal may be a consequence of the activation of both pyramidal cells and inhibitory interneurons. |
| | |
Authors:
|
Pia Enager; Henning Piilgaard; Nikolas Offenhauser; Ara Kocharyan; Priscilla Fernandes; Edith Hamel; Martin Lauritzen |
Related Documents
:
|
22155654 - Differential ascending projections of temporomandibular joint-responsive brainstem neur... 9345494 - Functional magnetic resonance image analysis of a large-scale neurocognitive network. 18482724 - Brain fiber tract plasticity in experimental spinal cord injury: diffusion tensor imaging. 18591474 - Intrinsic brain activity in altered states of consciousness: how conscious is the defau... 20118924 - Dichotomy of functional organization in the mouse auditory cortex. 2129874 - Oversized, auditory responsive units of rostral, mid, and posterolateral thalamus. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-01 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 29 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-30 Completed Date: 2009-05-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 976-86 Citation Subset: IM |
Affiliation:
|
Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej, Copenhagen N, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebrovascular Circulation / physiology* Electric Stimulation Evoked Potentials, Somatosensory / physiology Immunohistochemistry Interneurons / metabolism, physiology Laser-Doppler Flowmetry Male Neurons / metabolism*, physiology Oxygen Consumption / physiology* Pyramidal Cells / metabolism, physiology Rats Rats, Wistar Somatosensory Cortex / blood supply*, metabolism*, physiology Synaptic Potentials / physiology gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
|
56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Capturing adenylyl cyclases as potential drug targets.
Next Document: Blood lactate is an important energy source for the human brain.