| Pathway genetic load allows simultaneous evaluation of multiple genetic associations. | |
| | |
MedLine Citation:
|
PMID: 20381257 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: Despite the general success of genome-wide association studies, much heritability remains unidentified in many disease states. Some of this 'missing' heritability may lie in epistatic interactions among multiple loci, which are typically ignored. We utilized a method for simultaneous evaluation of epistatic interactions between allelic variations within genes confined to a single pathway, which we have termed as pathway genetic load (PGL). METHODS: In separate analyses, we evaluated the risk for sepsis and for death associated with alleles at six loci in the TLR4 signaling and response pathway previously known or suspected to be linked to the development of sepsis after traumatic injury. We evaluated 155 patients with > or =15% TBSA burns and without significant non-burn trauma [ISS < or =16], traumatic or anoxic brain injury or spinal cord injury, who survived > 48 h post-admission. Clinical data were collected prospectively and candidate genotypes were determined by TaqMan assay. RESULTS: After adjustment for burn size, inhalation injury, age, gender and race, PGL was associated with increased probability for complicated sepsis (aOR=1.59; 95%CI=1.11-2.29; p=0.011) and death (aOR=1.75; 95%CI=1.11-2.76; p=0.017). CONCLUSION: Relative size and variability of aORs indicate greater power to detect genetic associations with PGL compared to the analysis of loci individually by multivariate logistic regression. |
| | |
Authors:
|
Ryan M Huebinger; Harold R Garner; Robert C Barber |
Related Documents
:
|
20975947 - Genetic association study identifies hspb7 as a risk gene for idiopathic dilated cardio... 19376177 - Association of the macrophage migration inhibitory factor -173g/c polymorphism with cha... 22528397 - Genetic features of cerebrospinal fluid-derived subtype b hiv-1 tat. 22444037 - Genetic parameters for resistance to trichostrongylid infection in dairy sheep. 8954067 - Association of a mutation in thiazide-sensitive na-cl cotransporter with familial gitel... 18003637 - The conditional connexin43g138r mouse mutant represents a new model of hereditary oculo... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-08 |
Journal Detail:
|
Title: Burns : journal of the International Society for Burn Injuries Volume: 36 ISSN: 1879-1409 ISO Abbreviation: Burns Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-07-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8913178 Medline TA: Burns Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 787-92 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Ltd and ISBI. All rights reserved. |
Affiliation:
|
Department of Surgery, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
5P50GM21681-43/GM/NIGMS NIH HHS; 5T32GM008593-13/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Videocapillaroscopy in postburn scars: in vivo analysis of the microcirculation.
Next Document: Alcohol intake and its correlates in a transitional predominantly Muslim population in southeastern ...