Document Detail


Pathophysiology of venous leg ulceration.
MedLine Citation:
PMID:  9477037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The currently favoured hypothesis for the link between the raised venous pressure of chronic venous insufficiency and venous ulceration is based on the intermittent inappropriate activation of white blood cells. The damage initiated by the oxidative burst of the leucocyte leads to endothelial dysfunction, interstitial oedema, microthrombi and long-term microcirculatory damage including decreased capillary density. The net result is impairment of the potential for healing and hence ulceration.
Authors:
A Dormandy
Related Documents :
1388827 - Pressure and blood flow in pituitary adenomas measured during transsphenoidal surgery.
6804067 - Correction of the unfavourable effects of vasopressin by nitroglycerin infusion.
15379927 - Formation of cartilaginous foci in the central fibrous body of the heart in syrian hams...
659087 - Hemodynamic and morphologic evaluation of the spleen after splenic vein ligation in the...
3888067 - The pharmacologic treatment of portal hypertension.
18391097 - Structure-based identification of small-molecule angiotensin-converting enzyme 2 activa...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  17 Suppl 1     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  2-5     Citation Subset:  IM    
Affiliation:
St George's Hospital and Medical School, University of London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Endothelium, Vascular / physiopathology
Hemodynamics / physiology
Hemorheology
Hemostasis / physiology
Humans
Leg Ulcer / pathology,  physiopathology*
Leukocyte Disorders / physiopathology
Oxygen / blood
Venous Insufficiency / pathology,  physiopathology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Filler content and gap width after luting of ceramic inlays, using the ultrasonic insertion techniqu...
Next Document:  Effects of Daflon 500mg on postischemic macromolecular leak syndrome in striated skin muscle of the ...