Document Detail

Pathophysiology of venous leg ulceration.
MedLine Citation:
PMID:  9477037     Owner:  NLM     Status:  MEDLINE    
The currently favoured hypothesis for the link between the raised venous pressure of chronic venous insufficiency and venous ulceration is based on the intermittent inappropriate activation of white blood cells. The damage initiated by the oxidative burst of the leucocyte leads to endothelial dysfunction, interstitial oedema, microthrombi and long-term microcirculatory damage including decreased capillary density. The net result is impairment of the potential for healing and hence ulceration.
A Dormandy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  17 Suppl 1     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  2-5     Citation Subset:  IM    
St George's Hospital and Medical School, University of London, UK.
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MeSH Terms
Endothelium, Vascular / physiopathology
Hemodynamics / physiology
Hemostasis / physiology
Leg Ulcer / pathology,  physiopathology*
Leukocyte Disorders / physiopathology
Oxygen / blood
Venous Insufficiency / pathology,  physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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