| Pathophysiology of varicoceles in male infertility. | |
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MedLine Citation:
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PMID: 11556494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Varicoceles are found in 19 to 41% of infertile men, and is one treatable form of male infertility. The mechanism by which varicoceles cause the variable effect on male infertility and spermatogenesis is still unknown. Experimental animal models play a useful (but limited) role due to the sudden and variable iatrogenic nature of the varicoceles and the duration of the studies. Much of the human data are derived by the characterization of associated differences in measurable parameters between men with and without varicoceles. The role of hyperthermia, testicular blood flow and venous pressure changes, reflux of renal/adrenal products, hormonal dysfunction, autoimmunity, defects in acrosome reaction, and oxidative stress, in the pathophysiology of varicocele will be discussed. |
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Authors:
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C K Naughton; A K Nangia; A Agarwal |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Human reproduction update Volume: 7 ISSN: 1355-4786 ISO Abbreviation: Hum. Reprod. Update Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-09-14 Completed Date: 2002-02-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9507614 Medline TA: Hum Reprod Update Country: England |
Other Details:
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Languages: eng Pagination: 473-81 Citation Subset: IM |
Affiliation:
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Center for Advanced Research in Human Reproduction and Infertility, Department of Urology, The Cleveland Clinic Foundation, Ohio 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrosome Reaction Autoimmunity Fever / complications Hormones / physiology Humans Infertility, Male / etiology* Male Oxidative Stress Regional Blood Flow Testis / blood supply Varicocele / complications, physiopathology* Venous Pressure |
| Chemical | |
Reg. No./Substance:
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0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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