| Pathophysiology and triggers of acute myocardial infarction: clinical implications. | |
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MedLine Citation:
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PMID: 1350489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new approach to identification of the triggering mechanisms of acute myocardial infarction has been provided by the observation that the disease occurs more frequently during the morning hours compared to other times of day. This circadian variation results primarily from an increased relative risk during the initial 2-3 h after awakening and arising. The precise relationship between the onset of myocardial infarction and external factors such as activity and meal patterns needs to be determined in controlled epidemiologic studies. The possible underlying pathophysiologic mechanisms responsible for the circadian pattern of myocardial infarction include acute variations of blood pressure, heart rate, platelet aggregability and fibrinolytic activity, leading to an increased risk of plaque rupture and intracoronary thrombosis. Clinical implications of these findings include the need to design preventive regimens to provide maximum protection at the time of peak risk of myocardial infarction. |
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Authors:
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S N Willich; A H Jimenez; G H Tofler; R A DeSilva; J E Muller |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Clinical investigator Volume: 70 Suppl 1 ISSN: 0941-0198 ISO Abbreviation: Clin Investig Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-02 Completed Date: 1992-07-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9207154 Medline TA: Clin Investig Country: GERMANY |
Other Details:
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Languages: eng Pagination: S73-8 Citation Subset: IM |
Affiliation:
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Institute for Prevention of Cardiovascular Disease, Deaconess Hospital, Harvard Medical School, Boston. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Antihypertensive Agents / therapeutic use Arousal / drug effects, physiology Carbazoles / therapeutic use Circadian Rhythm / drug effects, physiology Coronary Artery Disease / physiopathology, prevention & control Coronary Circulation / drug effects, physiology* Humans Myocardial Infarction / physiopathology*, prevention & control Propanolamines / therapeutic use Risk Factors Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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