Document Detail

Pathophysiology and treatment of septic shock in neonates.
MedLine Citation:
PMID:  20569817     Owner:  NLM     Status:  MEDLINE    
Neonatal septic shock is a devastating condition associated with high morbidity and mortality. Definitions for the sepsis continuum and treatment algorithms specific for premature neonates are needed to improve studies of septic shock and assess benefit from clinical interventions. Unique features of the immature immune system and pathophysiologic responses to sepsis, particularly those of extremely preterm infants, necessitate that clinical trials consider them as a separate group. Keen clinical suspicion and knowledge of risk factors will help to identify those neonates at greatest risk for development of septic shock. Genomic and proteomic approaches, particularly those that use very small sample volumes, will increase our understanding of the pathophysiology and direct the development of novel agents for prevention and treatment of severe sepsis and shock in the neonate. Although at present antimicrobial therapy and supportive care remain the foundation of treatment, in the future immunomodulatory agents are likely to improve outcomes for this vulnerable population.
James L Wynn; Hector R Wong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  37     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-10-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-79     Citation Subset:  IM    
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University, 2424 Hock Plaza, Suite 504, DUMC Box 2739, Durham, NC 27710, USA. <>
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MeSH Terms
Acute-Phase Proteins / immunology
Anti-Infective Agents / therapeutic use
Blood Coagulation Disorders / immunology,  physiopathology
Complement System Proteins / immunology
Endothelium, Vascular / immunology
Genomics / methods
Hydrocortisone / therapeutic use
Immunity, Innate
Immunity, Maternally-Acquired
Infant, Newborn
Intercellular Signaling Peptides and Proteins / immunology
Multiple Organ Failure / immunology,  microbiology,  physiopathology,  therapy
Neutrophils / immunology
Opsonin Proteins / immunology
Proteomics / methods
Resuscitation / methods*
Risk Factors
Shock, Septic / immunology,  microbiology,  physiopathology*,  therapy*
Signal Transduction
Grant Support
R01 GM064619-06/GM/NIGMS NIH HHS; RC1 HL100474-01/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Anti-Infective Agents; 0/Intercellular Signaling Peptides and Proteins; 0/Opsonin Proteins; 50-23-7/Hydrocortisone; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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