| Pathophysiology and treatment of functional dyspepsia. | |
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MedLine Citation:
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PMID: 15798487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required. |
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Authors:
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Jan Tack; K J Lee |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 39 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-03-30 Completed Date: 2005-08-11 Revised Date: 2008-07-10 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: S211-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium. jan.tack@med.kuleuven.ac.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dyspepsia
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physiopathology*,
therapy* Enteric Nervous System / physiopathology* Gastrointestinal Agents / therapeutic use* Gastrointestinal Motility / drug effects, physiology Humans Psychotherapy / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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