Document Detail

Pathophysiology of sperm motility.
MedLine Citation:
PMID:  16368527     Owner:  NLM     Status:  MEDLINE    
Mammalian spermatozoa acquire the ability to swim during their transit from the testis to the oviduct under the control of several external and intracellular factors. These factors play also a pivotal role in regulating acquisition of hyperactivated motility and during the process of chemotaxis. This review summarizes the involvement of such factors in acquisition and maintenance of sperm motility, hyperactivation and chemotaxis, focusing in particular on the molecular bases of asthenozoospermia, a pathology of seminal plasma characterized by reduced sperm motility, which is one of the main causes of male infertility. Current in vitro treatments of asthenozoospermia are shown, together with the most recent findings on pharmacological and physiological molecules capable of stimulating sperm motility. The structure, function and mechanism of sperm flagellum responsible for the development of active motility are also analyzed in details.
Michaela Luconi; Gianni Forti; Elisabetta Baldi
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  11     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1433-47     Citation Subset:  IM    
Depatment of Clinical Physiopathology, Center of Research, Transfer and High Education, DENOthe, University of Florence.
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MeSH Terms
Allergy and Immunology
Calcium / metabolism
Flagella / metabolism
Genetic Predisposition to Disease
Genetic Variation
Infertility, Male
Models, Biological
Oligospermia / genetics*,  metabolism
Osmolar Concentration
Phosphoric Monoester Hydrolases / metabolism
Phosphotransferases / metabolism
Reactive Oxygen Species
Sperm Capacitation
Sperm Motility*
Spermatozoa / metabolism*
Testis / metabolism
Reg. No./Substance:
0/Reactive Oxygen Species; 7440-70-2/Calcium; EC 2.7.-/Phosphotransferases; EC 3.1.3.-/Phosphoric Monoester Hydrolases

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