Document Detail

[Pathophysiology of sepsis and possible influence of statins].
MedLine Citation:
PMID:  20960384     Owner:  NLM     Status:  MEDLINE    
Severe sepsis and septic shock are common complications in the intensive care unit and associated with high mortality. Early antimicrobial therapies together with organ-supportive measures are the major therapeutic approaches. However in the last decades immunomodulatory therapies have been investigated due to the notion of a compromised inflammatory response in septic patients. In addition to lowering circulating cholesterol, statins (HMG-CoA-reductase-inhibitors) have also been shown to possess pleiotropic anti-inflammatory potential. Recent studies indicate that these anti-inflammatory effects also modulate acute inflammatory response and therefore may play a protective role in septic patients. In this review, the pathophysiological background and first clinical trials of statins as a new adjuvant therapy in sepsis are summarized.
P Fraunberger; H Drexel; A K Walli
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Publication Detail:
Type:  English Abstract; Journal Article; Review     Date:  2010-10-19
Journal Detail:
Title:  Deutsche medizinische Wochenschrift (1946)     Volume:  135     ISSN:  1439-4413     ISO Abbreviation:  Dtsch. Med. Wochenschr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-20     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006723     Medline TA:  Dtsch Med Wochenschr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  2128-32     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Medizinisches Zentrallabor, Feldkirch, Österreich.
Vernacular Title:
Pathophysiologie der Sepsis und deren mögliche Beeinflussung durch HMG-CoA-Reduktase-Inhibitoren.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Anticholesteremic Agents / therapeutic use*
Cholesterol / blood
Clinical Trials as Topic
Coronary Disease / drug therapy,  immunology
Endotoxemia / drug therapy,  immunology,  mortality
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hypercholesterolemia / drug therapy,  immunology
Inflammation Mediators / blood
Intensive Care Units
Sepsis / drug therapy*,  immunology*,  mortality
Shock, Septic / drug therapy*,  immunology*,  mortality
Signal Transduction / drug effects
Survival Rate
Systemic Inflammatory Response Syndrome / drug therapy*,  immunology*,  mortality
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Inflammation Mediators; 57-88-5/Cholesterol

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