| [Pathophysiology of sepsis and possible influence of statins]. | |
| | |
MedLine Citation:
|
PMID: 20960384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Severe sepsis and septic shock are common complications in the intensive care unit and associated with high mortality. Early antimicrobial therapies together with organ-supportive measures are the major therapeutic approaches. However in the last decades immunomodulatory therapies have been investigated due to the notion of a compromised inflammatory response in septic patients. In addition to lowering circulating cholesterol, statins (HMG-CoA-reductase-inhibitors) have also been shown to possess pleiotropic anti-inflammatory potential. Recent studies indicate that these anti-inflammatory effects also modulate acute inflammatory response and therefore may play a protective role in septic patients. In this review, the pathophysiological background and first clinical trials of statins as a new adjuvant therapy in sepsis are summarized. |
| | |
Authors:
|
P Fraunberger; H Drexel; A K Walli |
Related Documents
:
|
16317384 - The activity of pathway-selective estrogen receptor ligands in experimental septic shock. 14763124 - Dealing with death: hmgb1 as a novel target for cancer therapy. 18591384 - Defective innate immunity predisposes murine neonates to poor sepsis outcome but is rev... 12942044 - Current advances in sepsis and septic shock with particular emphasis on the role of ins... 18827194 - Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for t... 19121674 - Construction of a reporter system to study burkholderia mallei type iii secretion and i... |
Publication Detail:
|
Type: English Abstract; Journal Article; Review Date: 2010-10-19 |
Journal Detail:
|
Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-20 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
|
Languages: ger Pagination: 2128-32 Citation Subset: IM |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Medizinisches Zentrallabor, Feldkirch, Österreich. pfraunberger@mzl.at |
Vernacular Title:
|
Pathophysiologie der Sepsis und deren mögliche Beeinflussung durch HMG-CoA-Reduktase-Inhibitoren. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Inflammatory Agents
/
therapeutic use* Anticholesteremic Agents / therapeutic use* Cholesterol / blood Clinical Trials as Topic Coronary Disease / drug therapy, immunology Endotoxemia / drug therapy, immunology, mortality Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / drug therapy, immunology Inflammation Mediators / blood Intensive Care Units Sepsis / drug therapy*, immunology*, mortality Shock, Septic / drug therapy*, immunology*, mortality Signal Transduction / drug effects Survival Rate Systemic Inflammatory Response Syndrome / drug therapy*, immunology*, mortality |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Inflammation Mediators; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rupture of a superior mesenteric artery aneurysm.
Next Document: 82-year-old patient with chronic cough, pulmonary infiltrations and eosinophilia.