Document Detail

Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model.
MedLine Citation:
PMID:  17350689     Owner:  NLM     Status:  MEDLINE    
Organophosphate (OP) poisoning causes a cholinergic crisis with a wide range of clinical effects including central apnea, pulmonary bronchoconstriction and secretions, seizures, and muscle weakness. The morbidity and mortality from acute OP poisoning is attributed to respiratory failure but the relative contributions of the central and peripheral effects in producing collapse of the respiratory system are unclear. In this study we used a novel adult rat model of acute OP poisoning to analyze the pathophysiology of acute OP poisoning. We found that poisoning caused rapidly lethal central apnea. In animals sustained with mechanical ventilation, we found that following central apnea there ensued progressive pulmonary insufficiency that was variable in timing and severity. Our findings support the hypothesis that OP poisoning in this animal model causes a sequential "two hit" insult, with rapid central apnea followed by delayed impairment of pulmonary gas exchange with prominent airway secretions.
Romolo J Gaspari; David Paydarfar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-02-11
Journal Detail:
Title:  Neurotoxicology     Volume:  28     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-10-18     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  664-71     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Anesthesia, General
Anesthesia, Inhalation
Blood Gas Analysis
Blood Pressure / drug effects
Carbon Dioxide / metabolism
Cholinesterase Inhibitors / poisoning*
Data Interpretation, Statistical
Dichlorvos / poisoning*
Heart Rate / drug effects
Pesticides / poisoning*
Pulmonary Gas Exchange
Rats, Wistar
Respiration, Artificial
Respiratory Insufficiency / chemically induced*,  physiopathology*
Grant Support
1K08 NS 048857/NS/NINDS NIH HHS; K08 NS048857/NS/NINDS NIH HHS; K08 NS048857-01A2/NS/NINDS NIH HHS
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Pesticides; 142M471B3J/Carbon Dioxide; 7U370BPS14/Dichlorvos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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