| Pathophysiology of polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 2513454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathophysiology of polycystic ovarian syndrome (PCO) is the subject of many hypotheses and speculations. In particular, the possible intervention in the starting and the maintenance of this syndrome of hyperprolactinemia, androgen hypersecretion, decreased FSH secretion is discussed. A primary abnormality at the level of the GnRH generator responsible for an increase of GnRH pulses frequency and amplitude remains an attractive hypothesis, at least in pure PCO syndrome. However, the possibility that other factors may contribute to the maintenance of a vicious circle of anovulation cannot be neglected. Regarding the treatment of chronic anovulation and hirsutism currently observed in PCO syndrome, only agents acting at the hypothalamic level are efficient, namely: clomiphene citrate for inducing ovulation and antigonadotropic therapies for improvement of hirsutism. These different possibilities are discussed. |
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Authors:
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P Mauvais-Jarvis; C Bricaire |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 33 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-02-06 Completed Date: 1990-02-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 791-4 Citation Subset: IM |
Affiliation:
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Department of Reproductive Endocrinology, Necker Hospital, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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secretion Clomiphene / pharmacology Estradiol / blood Female Follicle Stimulating Hormone / blood, secretion Humans Luteinizing Hormone / blood, secretion Pituitary Hormone-Releasing Hormones / metabolism Polycystic Ovary Syndrome / metabolism, physiopathology* Progesterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Pituitary Hormone-Releasing Hormones; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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