| Pathophysiology and pharmacology of the cardiac "late sodium current.". | |
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MedLine Citation:
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PMID: 18662720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The "late sodium current" (I(NaL)) is a sustained component of the fast Na+ current of cardiac myocytes and neurons. As recently appreciated, common neurological and cardiac conditions are associated with abnormal I(NaL) enhancement, which may contribute to the pathogenesis of both electrical and contractile dysfunction. For this reason, I(NaL) has become an appealing pharmacological target, with a potentially broad range of therapeutic indications. The recent approval by the FDA of an I(NaL) blocker (ranolazine) for clinical use justifies the increased interest in I(NaL) as a pathogenic mechanism and the rapid evolution of the information concerning it. The review focuses on cardiac aspects of I(NaL) enhancement; it deals with the origin of I(NaL), with its pathophysiological role and with the consequences of its pharmacological modulation. Both basic aspects and clinical evidence are discussed. |
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Authors:
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Antonio Zaza; Luiz Belardinelli; John C Shryock |
Publication Detail:
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Type: Journal Article; Review Date: 2008-07-01 |
Journal Detail:
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Title: Pharmacology & therapeutics Volume: 119 ISSN: 0163-7258 ISO Abbreviation: Pharmacol. Ther. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-08 Completed Date: 2009-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 326-39 Citation Subset: IM |
Affiliation:
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Dipartimento di Biotecnologie e Bioscienze, Università Milano-Bicocca Milano (IT), Italy. antonio.zaza@unimib.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetanilides
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pharmacology Action Potentials / drug effects Animals Heart Conduction System / drug effects*, metabolism, physiopathology Humans Models, Biological Piperazines / pharmacology Sodium / metabolism* Sodium Channel Blockers / pharmacology* Sodium Channels / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Acetanilides; 0/Piperazines; 0/Sodium Channel Blockers; 0/Sodium Channels; 110445-25-5/ranolazine; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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