Document Detail

Pathophysiology of overheating in a piglet model: findings compared with sudden infant death syndrome.
MedLine Citation:
PMID:  8860384     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the nature of hyperthermia-induced pathophysiological changes in an animal model including effects on lung compliance. METHODOLOGY: Piglets were randomly assigned to heated or non-heated groups. Heated animals were warmed to 4 degrees C above normal body temperature while sedated and breathing spontaneously. Cardiorespiratory variables were recorded serially and haematological assessments and blood cultures taken at 0 and 6 h. After 6 h the animals were killed and a limited postmortem was performed. Control animals had all procedures without heating. RESULTS: Heated piglets developed tachycardia, hypotension and a metabolic acidosis in addition to tachypnoea, hypocapnic alkalosis and a neutrophil leucocytosis. Rectal temperature after death fell at the same rate in both groups. Lung histology revealed an excess of lung haemorrhage and alveolar oedema in the heated group. No significant group differences in dynamic lung compliance were demonstrated. CONCLUSIONS: The pathological changes that occur during hyperthermia are non-specific but not incompatible with those found in sudden infant death syndrome. There was no confirmation of the thesis that hyperthermia causes death by altering lung compliance.
D E Elder; D P Bolton; A G Dempster; B J Taylor; R S Broadbent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  32     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-05-16     Completed Date:  1997-05-16     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Department of Paediatrics, University of Otago Medical School, Dunedin, New Zealand.
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MeSH Terms
Animals, Newborn
Disease Models, Animal*
Heat Stress Disorders / complications*,  pathology,  physiopathology*
Infant, Newborn
Lung Compliance
Pilot Projects
Postmortem Changes
Pulmonary Surfactants
Random Allocation
Sudden Infant Death / etiology*,  pathology
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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