Document Detail

Pathophysiology of oedema in idiopathic nephrotic syndrome.
MedLine Citation:
PMID:  12953039     Owner:  NLM     Status:  MEDLINE    
The decrease in plasma protein and colloid osmotic pressure (COP) in the nephrotic syndrome is accompanied by a decrease in tissue-fluid protein and COP. The latter protects against a fall in blood volume. However, the range and speed of this protective mechanism are limited, and a decrease in blood volume can be expected if plasma COP is below approximately 10 mmHg, or (temporarily) if the protein loss starts very fast. In addition, due to this protective mechanism volume retained by the kidneys cannot effectively expand blood volume, explaining that hypertension is rarely grave and pulmonary congestion unusual, whereas peripheral oedema can be gross. The renal derangement leading to volume retention involves a decreased filtration per nephron, increased tubular reabsorption, and decreased sensitivity to ANP but the relation between these changes is incompletely resolved.
Hein A Koomans
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  18 Suppl 6     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-03     Completed Date:  2004-03-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  vi30-2     Citation Subset:  IM    
Department of Nephrology and Hypertension, University Medical Center Utrecht, Room F03.226, PO Box 85500, 3508 GA Utrecht, The Netherlands.
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MeSH Terms
Edema / etiology*,  physiopathology*
Nephrotic Syndrome / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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