Document Detail

Pathophysiology of non-insulin-dependent diabetes mellitus (NIDDM).
MedLine Citation:
PMID:  8529505     Owner:  NLM     Status:  MEDLINE    
In this review, the pathophysiologycal events leading to hyperglycemia in NIDDM patients are discussed, i.e. glucose effectiveness, insulin action (in muscle and liver) and insulin secretion. The natural history of the insulin resistance syndrome is demonstrated and a new staging system is proposed. We conclude that NIDDM is a life-long disease characterized by intraabdominal obesity and macrovascular events several years in advance of hyperglycemia, and that insulin resistance in skeletal muscle plays an important pathophysiological part and also may be used in prediction of the disease.
H Beck-Nielsen; J E Henriksen; A Vaag; O Hother-Nielsen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  28 Suppl     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-01     Completed Date:  1996-02-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  S13-25     Citation Subset:  IM    
Diabetes Research Center, University of Odense, Denmark.
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MeSH Terms
Diabetes Mellitus / epidemiology,  physiopathology
Diabetes Mellitus, Type 2 / genetics,  metabolism,  physiopathology*
Diabetic Angiopathies / physiopathology
Glucose / metabolism
Hyperglycemia / metabolism
Insulin / physiology,  secretion
Insulin Resistance
Prediabetic State / physiopathology
Reference Values
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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