Document Detail

Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning.
MedLine Citation:
PMID:  18344027     Owner:  NLM     Status:  MEDLINE    
One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre- and postconditioning in patients with coronary artery disease.
Andreas Skyschally; Rainer Schulz; Gerd Heusch
Related Documents :
11515897 - Adenosine-enhanced ischemic preconditioning modulates necrosis and apoptosis: effects o...
17981547 - Making the heart resistant to infarction: how can we further decrease infarct size?
1394937 - Role of myocardial atp-sensitive potassium channels in mediating preconditioning in the...
10500207 - The late phase of ischemic preconditioning is abrogated by targeted disruption of the i...
1573777 - Prediction of life-threatening arrhythmia in patients after myocardial infarction by la...
6991187 - Brief review. hypertension and the heart.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Herz     Volume:  33     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  88-100     Citation Subset:  IM    
Institute of Pathophysiology,West German Heart Center, UniversityHospital Essen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apoptosis / physiology
Ischemic Preconditioning, Myocardial*
Myocardial Infarction / pathology,  physiopathology*,  therapy
Myocardial Reperfusion Injury / pathology,  physiopathology*,  prevention & control
Myocardium / pathology
Signal Transduction / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  VEGF165 expression in the tumor microenvironment influences the differentiation of bone marrow-deriv...
Next Document:  Optimizing systems of care for patients with acute myocardial infarction. STEMI networks, telemetry ...