Document Detail

Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning.
MedLine Citation:
PMID:  18344027     Owner:  NLM     Status:  MEDLINE    
One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre- and postconditioning in patients with coronary artery disease.
Andreas Skyschally; Rainer Schulz; Gerd Heusch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Herz     Volume:  33     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  88-100     Citation Subset:  IM    
Institute of Pathophysiology,West German Heart Center, UniversityHospital Essen, Germany.
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MeSH Terms
Apoptosis / physiology
Ischemic Preconditioning, Myocardial*
Myocardial Infarction / pathology,  physiopathology*,  therapy
Myocardial Reperfusion Injury / pathology,  physiopathology*,  prevention & control
Myocardium / pathology
Signal Transduction / physiology

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