Document Detail

Pathophysiology and management of acute gastric mucosal hemorrhage.
MedLine Citation:
PMID:  732049     Owner:  NLM     Status:  MEDLINE    
Unlike hemorrhage from peptic ulcer, surgical management for hemorrhage from stress ulcer is not necessarily successful on many occasions. Thus, the most important thing one can try is to prevent the development of this condition. Forty eight patients admitted to the Shock and Trauma Unit, Hahnemann Medical College and Hospital, who had a primary diagnosis of shock were divided into three groups: group 1 received the standard shock regimen plus large dose steroid therapy repeated every four hours for 36 hours; group 2 received the standard shock regimen plus small dose steroid therapy repeated every four hours for 96 hours; group 3 received the standard shock regimen without the addition of steroids. There was a 57.9 per cent incidence of acute gastric ulceration in those shock patients not treated with steroids (group 3) compared with 33.3 per cent incidence of gastric ulceration in group 2 and 5.9 per cent incidence in group 1. The use of pharmacologic doses of steroids early in the shock state for period of less than 36 hours seems to reduce the incidence of gastric ulceration and hemorrhage in low flow states associated with septic, cardiogenic and hemorrhagic shock.
T Matsumoto; N Kaibara; K Sugimachi; Y Kawarada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of surgery     Volume:  8     ISSN:  0047-1909     ISO Abbreviation:  Jpn J Surg     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1302176     Medline TA:  Jpn J Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Cimetidine / therapeutic use
Gastric Mucosa
Peptic Ulcer / prevention & control
Peptic Ulcer Hemorrhage / physiopathology,  prevention & control,  therapy*
Prostaglandins E / therapeutic use
Shock, Traumatic / therapy
Steroids / therapeutic use
Stress, Physiological / drug therapy
Reg. No./Substance:
0/Prostaglandins E; 0/Steroids; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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