Document Detail

Pathophysiology of irreversible ischemic injury. The border zone controversy.
MedLine Citation:
PMID:  6344164     Owner:  NLM     Status:  MEDLINE    
At the present time our experimental findings plus the weight of other experimental evidence suggest that there is unlikely to be a quantitatively significant border zone in the lateral plane. The transition from normal to ischemic tissue is likely to be accomplished over a distance of 1.0 mm or less and possibly in as little as the dimensions of one cell. The situation in the transmural plane is less well established, but if the same situation occurs, then the absence of a spatially indentifiable border zone of intermediate injury will require a major reappraisal, although not an abandonment, of concepts for the therapeutic limitation of infarct size. Any extrapolation of the observations, comments, and conclusions made in this paper to the human heart should be made with extreme caution. Major species differences exist, particularly in relation to the characteristics of collateral flow. Most experimental studies have involved single or multiple coronary artery ligation, a situation that generates large areas of sharply demarcated ischemia. These areas are very severely ischemic and short of reperfusion, which is hardly a practical consideration in the early phases of evolving myocardial infarction; the affected tissue is inevitably condemned to cell death and necrosis. The situation prevailing in man with partial coronary artery occlusion or diffuse ischemic heart disease may well be be very different and is clearly in urgent need of investigation.
D J Hearse; D M Yellon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in myocardiology     Volume:  4     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-61     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Coronary Circulation
Coronary Disease / metabolism,  pathology*,  physiopathology
NAD / metabolism
Stereotaxic Techniques
Reg. No./Substance:
53-84-9/NAD; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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