Document Detail

Pathophysiology of hypocalciuria in preeclampsia: measurement of intestinal calcium absorption.
MedLine Citation:
PMID:  8290187     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze calcium absorption using stable isotopes in patients with preeclampsia and in normotensive controls. METHODS: Fifteen pregnant subjects were studied: eight with preeclampsia (hypertension and proteinuria) and seven normotensive controls. All patients were ingesting their normal diet. The subjects received two stable calcium isotopic tracers. An oral tracer (44Ca, 0.0124 mmol/kg) was given with milk, while an intravenous tracer (42Ca, 0.00249 mmol/kg) was infused over 7-10 minutes. Calcium concentration was determined by atomic absorption spectrophotometry, and isotope ratios by thermal ionization mass spectrometry from pooled 24-hour urine samples. RESULTS: No difference was noted in fractional intestinal absorption between preeclamptic subjects (0.282 +/- 0.051) and normotensive controls (0.306 +/- 0.079) (P = .49). However, the fraction of dietary calcium appearing in the urine differed significantly (0.06 for preeclamptic subjects and 0.087 for normotensive controls; P = .008). CONCLUSIONS: Despite the indirect evidence of others, calcium absorption does not appear to be impaired in patients with preeclampsia. The retention site of the unexcreted calcium is unidentified.
A Tolaymat; L Sanchez-Ramos; A L Yergey; N E Vieira; S A Abrams; P Edelstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  83     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-02-24     Completed Date:  1994-02-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Florida Health Science Center/Jacksonville.
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MeSH Terms
Calcium / metabolism,  urine*
Calcium Isotopes
Calcium, Dietary / pharmacokinetics*
Intestinal Absorption / physiology*
Pre-Eclampsia / physiopathology,  urine*
Reg. No./Substance:
0/Calcium Isotopes; 0/Calcium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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