Document Detail

Pathophysiology of hydrops fetalis.
MedLine Citation:
PMID:  8822328     Owner:  NLM     Status:  MEDLINE    
Hydrops fetalis occurs when the rate of interstitial fluid production by capillary ultrafiltration exceeds the rate of interstitial fluid return to the circulation via lymphatic vessels. Developmental differences in the microcirculation and lymphatic system of the fetus, as compared with mature subjects, renders the fetus susceptible to interstitial fluid accumulation. These differences include greater capillary permeability, more compliant interstitial compartment, and greater influence of venous pressures on lymphatic return. The balance between interstitial fluid production and removal is most commonly disrupted as a consequence of homeostatic mechanisms serving to preserve adequate systemic delivery of metabolic substrate when cardiocirculatory function is impaired. The pathophysiology of two conditions of impaired cardiocirculatory function, atrial tachycardia and severe anemia, serve as examples of the mechanisms by which these homeostatic mechanisms perturb the balance of interstitial fluid movement.
M Apkon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  19     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  437-46     Citation Subset:  IM    
Division of Critical Care, Yale University School of Medicine, New Haven, CT 06520-8064, USA.
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MeSH Terms
Capillary Permeability / physiology*
Extracellular Space / physiology*
Hydrops Fetalis / etiology,  physiopathology*
Lymphatic System / physiology*
Microcirculation / physiology
Nutritional Physiological Phenomena*
Oxygen / pharmacokinetics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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