| Pathophysiology of hydrops fetalis. | |
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MedLine Citation:
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PMID: 8822328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydrops fetalis occurs when the rate of interstitial fluid production by capillary ultrafiltration exceeds the rate of interstitial fluid return to the circulation via lymphatic vessels. Developmental differences in the microcirculation and lymphatic system of the fetus, as compared with mature subjects, renders the fetus susceptible to interstitial fluid accumulation. These differences include greater capillary permeability, more compliant interstitial compartment, and greater influence of venous pressures on lymphatic return. The balance between interstitial fluid production and removal is most commonly disrupted as a consequence of homeostatic mechanisms serving to preserve adequate systemic delivery of metabolic substrate when cardiocirculatory function is impaired. The pathophysiology of two conditions of impaired cardiocirculatory function, atrial tachycardia and severe anemia, serve as examples of the mechanisms by which these homeostatic mechanisms perturb the balance of interstitial fluid movement. |
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Authors:
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M Apkon |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 19 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-11-14 Completed Date: 1996-11-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 437-46 Citation Subset: IM |
Affiliation:
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Division of Critical Care, Yale University School of Medicine, New Haven, CT 06520-8064, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Capillary Permeability
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physiology* Extracellular Space / physiology* Humans Hydrops Fetalis / etiology, physiopathology* Lymphatic System / physiology* Microcirculation / physiology Nutritional Physiological Phenomena* Oxygen / pharmacokinetics* Ultrafiltration |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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