| Pathophysiology of human genetic CD36 deficiency. | |
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MedLine Citation:
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PMID: 12732446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD36, originally identified as glycoprotein IV on platelets, is an 88-kDa integral membrane protein that has multiple ligands and is expressed in the cardiovascular system (ie, blood vessel walls and the heart). Human genetic CD36 deficiency is relatively frequent in Asian and African populations. Investigation into the pathophysiology of this disorder has shown that CD36 may play an important role as a major scavenger receptor for oxidized low-density lipoproteins and as a crucial transporter for long-chain fatty acids. The CD36 deficiency may be related to the phenotypic expression of the "metabolic syndrome," which is frequently associated with atherosclerotic cardiovascular diseases. It also has been reported that CD36 deficiency might be linked with cardiomyopathy. These data raised the possibility that CD36 deficiency might be an important genetic background for these life-threatening human cardiovascular diseases. |
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Authors:
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Ken-ichi Hirano; Takahiro Kuwasako; Yumiko Nakagawa-Toyama; Mohamed Janabi; Shizuya Yamashita; Yuji Matsuzawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 13 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-06 Completed Date: 2003-09-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan. khirano@kb3.so-net.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD36 / genetics*, metabolism* Cardiovascular Diseases / genetics, metabolism, physiopathology Humans Myocytes, Cardiac / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD36 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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