| Pathophysiology of gastroesophageal reflux. | |
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MedLine Citation:
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PMID: 2658576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The factors controlling competence of the gastroesophageal junction have been carefully analyzed over the last decade. Although the presence of an anatomic sphincter guarding the lower esophagus has not been confirmed in humans, a manometrically defined high-pressure zone is present in the lower esophagus. The magnitude of sphincter pressure correlates well with the incidence of pathologic gastroesophageal reflux. Another important determinant of cardial competence is the length of intra-abdominal esophagus. The interaction of length and pressure in maintaining competence is demonstrated by several clinical and experimental studies. Twenty percent of refluxors have normal components of cardial competence. Several physical factors, namely components of Laplace's law, may govern control of reflux especially after antireflux repairs. The occurrence of esophagitis as a complication of gastroesophageal reflux is determined by the ability of the esophageal body to rid itself of an acid load as well as by factors that delay gastric emptying. |
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Authors:
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N K Altorki; D B Skinner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of medicine Volume: 86 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-06 Completed Date: 1989-07-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 685-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiothoracic Surgery, New York Hospital-Cornell Medical Center, New York 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Esophagogastric Junction / physiopathology Esophagus / physiopathology Gastric Acidity Determination Gastric Emptying Gastroesophageal Reflux / diagnosis, etiology, physiopathology* Humans Hydrogen-Ion Concentration Manometry |
| Comments/Corrections | |
Erratum In:
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Am J Med 1989 Sep;87(3):365 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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