Document Detail


Pathophysiology of gastroesophageal reflux.
MedLine Citation:
PMID:  2658576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The factors controlling competence of the gastroesophageal junction have been carefully analyzed over the last decade. Although the presence of an anatomic sphincter guarding the lower esophagus has not been confirmed in humans, a manometrically defined high-pressure zone is present in the lower esophagus. The magnitude of sphincter pressure correlates well with the incidence of pathologic gastroesophageal reflux. Another important determinant of cardial competence is the length of intra-abdominal esophagus. The interaction of length and pressure in maintaining competence is demonstrated by several clinical and experimental studies. Twenty percent of refluxors have normal components of cardial competence. Several physical factors, namely components of Laplace's law, may govern control of reflux especially after antireflux repairs. The occurrence of esophagitis as a complication of gastroesophageal reflux is determined by the ability of the esophageal body to rid itself of an acid load as well as by factors that delay gastric emptying.
Authors:
N K Altorki; D B Skinner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  86     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-06     Completed Date:  1989-07-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiothoracic Surgery, New York Hospital-Cornell Medical Center, New York 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Esophagogastric Junction / physiopathology
Esophagus / physiopathology
Gastric Acidity Determination
Gastric Emptying
Gastroesophageal Reflux / diagnosis,  etiology,  physiopathology*
Humans
Hydrogen-Ion Concentration
Manometry
Comments/Corrections
Erratum In:
Am J Med 1989 Sep;87(3):365

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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