Document Detail

Pathophysiology of food-induced anaphylaxis.
MedLine Citation:
PMID:  18589838     Owner:  NLM     Status:  MEDLINE    
Food-induced anaphylaxis is a steadily increasing problem in westernized countries and now represents the leading cause of anaphylaxis in the outpatient setting, particularly in children. Much of our knowledge of the pathophysiology of food-induced anaphylaxis comes from animal studies. Food anaphylaxis in humans is thought to be entirely IgE mediated. Several features appear to be unique to these reactions; factors such as exercise can lower the "threshold" for anaphylaxis in certain susceptible individuals. Different methods of thermal processing can modify the allergenicity of food proteins. Alteration of stomach pH can allow for incomplete digestion of food proteins, leading to increased absorption of intact food allergens. Low serum platelet-activating factor acetylhydrolase may predispose to fatal food-induced anaphylaxis. With a greater understanding of the pathophysiology of food-induced anaphylaxis, novel approaches not only to identify those at risk, but to treat and ultimately prevent food-induced anaphylaxis, are on the horizon.
Heather Lemon-Mulé; Anna Nowak-Wegrzyn; Cecilia Berin; Adina K Knight
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  8     ISSN:  1529-7322     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
University of Alabama at Birmingham, Birmingham, AL 35209, USA.
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MeSH Terms
Anaphylaxis / diagnosis,  etiology*,  physiopathology,  therapy
Antigens / metabolism
Basophils / physiology
Disease Models, Animal
Food Hypersensitivity / diagnosis,  etiology,  physiopathology,  therapy
Immunoglobulin E / immunology
Mast Cells / physiology
Reg. No./Substance:
0/Antigens; 37341-29-0/Immunoglobulin E

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