Document Detail

Pathophysiology of food allergy.
MedLine Citation:
PMID:  21453807     Owner:  NLM     Status:  MEDLINE    
In this article we review the pathophysiology of food allergy, which affects 4% of US children and 2% of adults, and is increasing in prevalence. Most food allergens share certain specific physicochemical characteristics that allow them to resist digestion, thus enhancing allergenicity. During allergic sensitization, these allergens are encountered by specialized dendritic cell populations in the gut, which leads to T-cell priming and the production of allergen-specific IgE production by B cells. Tissue-resident mast cells then bind IgE, and allergic reactions are elicited when mast cells are reexposed to allergen. Adjacent IgE molecules bound to the surface of the mast cell become cross-linked, causing mast cell degranulation and release of powerful vasoactive compounds that cause allergic symptoms.
Brian P Vickery; Stacy Chin; A Wesley Burks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-05
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  58     ISSN:  1557-8240     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-01     Completed Date:  2011-06-28     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-76, ix-x     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Allergens / immunology
B-Lymphocytes / immunology
Food Hypersensitivity / epidemiology,  immunology,  physiopathology*
Immunoglobulin E / immunology
Mast Cells / immunology
T-Lymphocytes / immunology
United States / epidemiology
Grant Support
1 R01-AI06874-01A1/AI/NIAID NIH HHS; 1 UL1 RR024128-01/RR/NCRR NIH HHS; R01 AI068074/AI/NIAID NIH HHS; R01 AI068074-05/AI/NIAID NIH HHS; T32 AI007062/AI/NIAID NIH HHS; T32 AI007062-32/AI/NIAID NIH HHS
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

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