| Pathophysiology of food allergy. | |
| | |
MedLine Citation:
|
PMID: 21453807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this article we review the pathophysiology of food allergy, which affects 4% of US children and 2% of adults, and is increasing in prevalence. Most food allergens share certain specific physicochemical characteristics that allow them to resist digestion, thus enhancing allergenicity. During allergic sensitization, these allergens are encountered by specialized dendritic cell populations in the gut, which leads to T-cell priming and the production of allergen-specific IgE production by B cells. Tissue-resident mast cells then bind IgE, and allergic reactions are elicited when mast cells are reexposed to allergen. Adjacent IgE molecules bound to the surface of the mast cell become cross-linked, causing mast cell degranulation and release of powerful vasoactive compounds that cause allergic symptoms. |
| | |
Authors:
|
Brian P Vickery; Stacy Chin; A Wesley Burks |
Related Documents
:
|
21535687 - Effects of nutritional and environmental conditions on salmonella sp. biofilm formation. 22980007 - Immunomagnetic capture of bacillus anthracis spores from food. 22560457 - Performance standards and meat safety - developments and direction. 23605867 - The system approach to the identification of aflatoxigenic fungi in foodstuffs and feed... 15127067 - Food safety education: health professionals' knowledge and assessment of wic client needs. 12859707 - The food standards agency's antioxidants in food programme--a summary. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-03-05 |
Journal Detail:
|
Title: Pediatric clinics of North America Volume: 58 ISSN: 1557-8240 ISO Abbreviation: Pediatr. Clin. North Am. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-01 Completed Date: 2011-06-28 Revised Date: 2012-09-24 |
Medline Journal Info:
|
Nlm Unique ID: 0401126 Medline TA: Pediatr Clin North Am Country: United States |
Other Details:
|
Languages: eng Pagination: 363-76, ix-x Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Box 2644, Durham, NC 27710, USA. brian.vickery@duke.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allergens
/
immunology B-Lymphocytes / immunology Child Food Hypersensitivity / epidemiology, immunology, physiopathology* Humans Immunoglobulin E / immunology Mast Cells / immunology Prevalence T-Lymphocytes / immunology United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
1 R01-AI06874-01A1/AI/NIAID NIH HHS; 1 UL1 RR024128-01/RR/NCRR NIH HHS; R01 AI068074-05/AI/NIAID NIH HHS; T32 AI007062-32/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Allergens; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnostic testing in the evaluation of food allergy.
Next Document: Recognition and management of food-induced anaphylaxis.