| Pathophysiology of delirium in the intensive care unit. | |
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MedLine Citation:
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PMID: 18241778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delirium, or acute brain dysfunction, is a life-threatening global disturbance in cognitive functioning that frequently manifests in critically ill patients. This review examines the current status of knowledge regarding the pathophysiology of delirium in the ICU, in particular, evaluating the role of iatrogenic factors such as sedatives and analgesic administration in brain dysfunction. This hypothesis is considered along with several other plausible mechanisms of ICU delirium, including sepsis, postoperative cognitive dysfunction, and changes in biomarkers and neurotransmitters. The review concludes by highlighting potential future directions in molecular genetics for the elucidation of delirium and its long-term consequences. |
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Authors:
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Max L Gunther; Alessandro Morandi; E Wesley Ely |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care clinics Volume: 24 ISSN: 0749-0704 ISO Abbreviation: Crit Care Clin Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-02-04 Completed Date: 2008-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507720 Medline TA: Crit Care Clin Country: United States |
Other Details:
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Languages: eng Pagination: 45-65, viii Citation Subset: IM |
Affiliation:
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VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212-2637, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood,
metabolism Delirium / etiology, metabolism, physiopathology* Humans Intensive Care Units* Molecular Biology / trends Neurotransmitter Agents* / biosynthesis, metabolism, physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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