Document Detail

Pathophysiology of delirium in the intensive care unit.
MedLine Citation:
PMID:  18241778     Owner:  NLM     Status:  MEDLINE    
Delirium, or acute brain dysfunction, is a life-threatening global disturbance in cognitive functioning that frequently manifests in critically ill patients. This review examines the current status of knowledge regarding the pathophysiology of delirium in the ICU, in particular, evaluating the role of iatrogenic factors such as sedatives and analgesic administration in brain dysfunction. This hypothesis is considered along with several other plausible mechanisms of ICU delirium, including sepsis, postoperative cognitive dysfunction, and changes in biomarkers and neurotransmitters. The review concludes by highlighting potential future directions in molecular genetics for the elucidation of delirium and its long-term consequences.
Max L Gunther; Alessandro Morandi; E Wesley Ely
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care clinics     Volume:  24     ISSN:  0749-0704     ISO Abbreviation:  Crit Care Clin     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507720     Medline TA:  Crit Care Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-65, viii     Citation Subset:  IM    
VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212-2637, USA.
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MeSH Terms
Biological Markers / blood,  metabolism
Delirium / etiology,  metabolism,  physiopathology*
Intensive Care Units*
Molecular Biology / trends
Neurotransmitter Agents* / biosynthesis,  metabolism,  physiology
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Neurotransmitter Agents

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