| Pathophysiology of critical ill patients: focus on critical oxygen delivery. | |
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MedLine Citation:
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PMID: 18838756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Critical ill patients experience acute physiological changes because the body cannot fulfill the oxygen demand to perform normal aerobic metabolism. Factors determining oxygen delivery include cardiac output, hemoglobin, and oxygen saturation. Incapability to fulfill adequate oxygen of the body to produce adenosine triphosphate (ATP) may occur due to decreased oxygen delivery and/or increased oxygen consumption. A condition in which oxygen consumption becomes very dependent on oxygen delivery is called critical oxygen delivery. Parameters to evaluate the adequate oxygen delivery to meet the oxygen consumption are central vein oxygen saturation (SvO2), serum lactate, oxygen extraction ratio (O2ER). A comprehension about oxygen delivery and consumption is very important to overcome tissue hypoxia and various factors in critical ill patients. |
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Authors:
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Arif Mansjoer; Yohanes W H George |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Indonesiana Volume: 40 ISSN: 0125-9326 ISO Abbreviation: Acta Med Indones Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-10-07 Completed Date: 2009-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901042 Medline TA: Acta Med Indones Country: Indonesia |
Other Details:
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Languages: eng Pagination: 161-70 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo Hospital, Jalan Diponegoro no. 71, Jakarta. arif.mansjoer@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adenosine Triphosphate / metabolism Anoxia / physiopathology, therapy* Cardiac Output Cell Hypoxia Critical Illness* Humans Lactic Acid / blood, metabolism Oximetry / methods Oxygen Consumption* Oxygen Inhalation Therapy* |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate |
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