Document Detail


Pathophysiology of chronic urticaria.
MedLine Citation:
PMID:  18450112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). DATA SOURCES: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. STUDY SELECTION: The authors selected relevant and current sources for inclusion in this review. RESULTS: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. CONCLUSION: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.
Authors:
Lindsey A Brodell; Lisa A Beck; Sarbjit S Saini
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  100     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-7; quiz 297-9, 322     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Autoimmunity / immunology
Basophils / immunology
Chronic Disease
Histamine Release / immunology
Humans
Mast Cells / immunology
Urticaria / diagnosis,  immunology*
Grant Support
ID/Acronym/Agency:
AI070345/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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