| Pathophysiology of chronic urticaria. | |
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MedLine Citation:
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PMID: 18450112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). DATA SOURCES: PubMed was searched using the keywords urticaria and either chronic or autoimmune or pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. STUDY SELECTION: The authors selected relevant and current sources for inclusion in this review. RESULTS: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. CONCLUSION: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments. |
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Authors:
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Lindsey A Brodell; Lisa A Beck; Sarbjit S Saini |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 100 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 291-7; quiz 297-9, 322 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity
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immunology Basophils / immunology Chronic Disease Histamine Release / immunology Humans Mast Cells / immunology Urticaria / diagnosis, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI070345/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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