| Pathophysiology of chronic rhinosinusitis with nasal polyp. | |
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MedLine Citation:
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PMID: 22186239 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Chronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses and nasal passages. CRS with nasal polyp (CRSwNP) is a subtype of CRS, and the pathogenesis of CRSwNP remains largely unclear. METHODS: This article reviews the literature regarding the pathophysiology of CRSwNP. RESULTS: Evidence suggests that altered innate immunity, adaptive immunity, tissue remodeling, and/or effects of microorganisms may play a role in the development of CRSwNP. Aberrant arachidonic acid metabolism may also contribute to the pathogenesis of CRSwNP in patients with aspirin-exacerbated respiratory disease. CONCLUSION: There have been significant advances in the understanding pathophysiology of CRSwNP. Additional research is needed to elucidate these mechanisms and to determine their relative importance in the pathogenesis of CRSwNP. |
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Authors:
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Joy Hsu; Anju T Peters |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of rhinology & allergy Volume: 25 ISSN: 1945-8932 ISO Abbreviation: Am J Rhinol Allergy Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490775 Medline TA: Am J Rhinol Allergy Country: United States |
Other Details:
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Languages: eng Pagination: 285-90 Citation Subset: IM |
Affiliation:
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Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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