Document Detail

Pathophysiology of cardiovascular dysfunction in septic shock.
MedLine Citation:
PMID:  9654320     Owner:  NLM     Status:  MEDLINE    
Sepsis and septic shock are common problems in the ICU and carry a very high mortality. Myocardial depression is a common finding in patients with sepsis, and is usually reversible as the patient recovers. Both exogenous mediators, such as endotoxin, and endogenous cytokines, including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, have been implicated as important factors in the pathophysiology of septic shock and the development of myocardial depression in sepsis. Nitric oxide has also been implicated in the pathophysiology of the cardiovascular response to sepsis. Better understanding of the roles and interactions of these substances will be necessary to develop more effective therapies without increasing morbidity and mortality.
M M Parker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  New horizons (Baltimore, Md.)     Volume:  6     ISSN:  1063-7389     ISO Abbreviation:  New Horiz     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-10     Completed Date:  1998-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9416195     Medline TA:  New Horiz     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
Department of Pediatrics, SUNY at Stony Brook, NY 11794-8111, USA.
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MeSH Terms
Cardiac Output, Low / physiopathology
Cardiovascular System / physiopathology*
Cytokines / metabolism
Endotoxins / metabolism
Hemodynamics / physiology*
Nitric Oxide / metabolism
Oxygen / metabolism
Shock, Septic / physiopathology*
Reg. No./Substance:
0/Cytokines; 0/Endotoxins; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

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